Protective Effects of MAK-4 and MAK-5 on Adriamycin-Induced Microsomal Lipid Peroxidation and Mortality
Biochemical Archives, Vol. 8, pp. 267-272, 1992.
Ferzaan N. Engineer,* Hari M. Sharma,** and Chandradhar Dwivedi.*
**College of Pharmacy, South Dakota State University, Brookings, SD
**College of Medicine, The Ohio State University, Columbus, OH
Use of the chemotherapeutic agent Adriamycin is complicated by its potentially lethal cardiac toxicity. DNA base pair damage induced by Adriamycin results in its effectiveness against cancer; however, simultaneous production of free radicals results in toxic side effects. In this study on mice, Adriamycin-induced mortality reached 60% in the control group (regular chow diet), compared to 20% in the group receiving a 6% MAK-4-supplemented diet (p<0.05), and 40% in the group receiving a 0.2% MAK-5-supplemented diet.
See Antioxidant Research for more information on this study.
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