Antineoplastic Properties of Maharishi-4 [MAK-4] Against DMBA-Induced Mammary Tumors in Rats
Pharmacology, Biochemistry and Behavior, Vol. 35, pp. 767-773, 1990.
Hari M. Sharma,* Chandradhar Dwivedi,** Bryan C. Satter,** Krishnamurthy P. Gudehithlu,* Hussein Abou-Issa,* William Malarkey,* and Gopi A. Tejwani.*
**College of Medicine, The Ohio State University, Columbus OH 43210
**College of Pharmacy, South Dakota State University, Brookings, SD 57007
The herbal mixture MAK-4 (Maharishi Amrit Kalash-4) was tested for anticarcinogenic and anticancer properties against 7,12–dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats. The 6% MAK-4-supplemented diet protected against DMBA-induced carcinogenesis by reducing both tumor incidence and multiplicity during initiation and promotion phases. MAK-4 provided up to 88% protection (p<0.05) during the promotion phase, and 60% (p<0.05) during the initiation phase of carcinogenesis. Also, 60% of the control animals which had developed fully-formed tumors showed tumor regression when their diet was subsequently supplemented with MAK-4 for four weeks. In 50% of these rats, the tumor regressed completely. There was no significant difference in the food intake or weight gain in rats on the MAK-4-supplemented diet compared to the control group.
© 1999, 2021 Maharishi AyurVeda Products International, Inc. (MAPI). All Rights Reserved. MAPI does not provide medical advice, diagnosis or treatment. These statements have not been evaluated by the Food and Drug Administration. Products are not intended to diagnose, treat, cure or prevent any disease. See additional information.