Antineoplastic Properties of Maharishi Amrit Kalash [MAK-5], An Ayurvedic Food Supplement, Against 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Rats
Journal of Research and Education in Indian Medicine, Vol. 10, No. 3, pp. 1-8, July-September 1991.
Hari M. Sharma,* Chandradhar Dwivedi,** Bryan C. Satter,** and Hussein Abou-Issa.*
**College of Medicine, The Ohio State University, Columbus, OH 43210
**College of Pharmacy, South Dakota State University, Brookings, SD 57007
The herbal mixture Maharishi Amrit Kalash-5 (MAK-5) was tested for antineoplastic properties against 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats. The 0.2% (w/w) MAK-5-supplemented diet protected against DMBA-induced carcinogenesis during the promotion phase by reducing both tumor incidence and multiplicity. MAK-5 provided up to 62.5% protection (p<0.05) during the promotion phase of carcinogenesis. Also, a MAK-5-supplemented diet fed for four weeks to control rats which had developed mammary tumors, decreased tumor size in 60% of these rats.
There was no significant difference in weight gain in rats on the MAK-5-supplemented diet. Thus, the MAK-5-supplemented diet did not influence the food intake, but protected against DMBA-induced mammary tumors in rats.
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