Effect of the Herbal Mixture MAK-4 on Organ Functions in Watanabe Heritable Hyperlipidemic (WHHL) Rabbits.
Biochemical Archives, Vol. 13, pp. 285-296, 1997.
Jae Y. Lee, John A. Lott, Ellen M. Kauffman, and Hari M. Sharma.
Department of Pathology, College of Medicine, The Ohio State University, Columbus, OH 43210
This study assessed the organ-protective effects of MAK-4 which was fed to Watanabe Heritable Hyperlipidemic (WHHL) rabbits. The control group (n = 5) was fed normal rabbit chow and the experimental group (n = 6) was fed 6% (w/w) MAK-4-supplemented chow, for 6 months. Blood specimens were drawn from the ear vein at the start of the experiment before MAK-4 was given, and after 2, 4, and 6 months of MAK-4 ingestion. Twenty-four-hour urines were collected between the 25th and 26th week. Various biochemical parameters were assessed, including tests for liver function, kidney function, pancreatic function, enzymes, and other tests for tissue damage. Results showed that albumin, fibrinogen, and total protein were significantly higher (p <0.05) in the MAK-4 group compared to the control group. Gamma glutamyl transferase, creatine kinase, creatine kinase-MM isoenzyme, and lipid peroxide were significantly decreased in the MAK-4-treated group as compared to the controls. Creatinine, urine inorganic phosphorus, urine uric acid, urine amylase, and urine glucose were significantly lower (p <0.05) in the MAK-4 group compared activity, mean corpuscular hemoglobin concentration, and superoxide dismutase were significantly increased (p <0.05) in the MAK-4 group compared to the controls. These findings suggest prevention of organ damage in the MAK-4-supplemented rabbits. The mechanism of action may be prevention of lipid and protein oxidation by MAK-4.
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