Effects of Ayurvedic Food Supplement MAK-4 on Cisplatin-Induced Changes in Glutathione and Glutathione-S-transferase Activity
Rao, R.S., Deo, M.G., and Sanghvi, L.D. (eds). Proceedings of the XVI International Cancer Congress. Bologna, Italy: Monduzzi Editore, 1994: 589-592.
H. Sharma,* J. Guenther,** A. Abu-Ghazaleh,** and C. Dwivedi.**
**The Ohio State University, Columbus, OH
**South Dakota State University, Brookings, SD
Cisplatin, a chemotherapeutic drug used to treat testicular, ovarian, and other cancers, causes toxic side effects in the kidneys. A decrease in glutathione (GSH) and glutathione-S-transferase (GST) activities may play a role in this nephrotoxicity. This study on cisplatin and MAK-4 showed that cisplatin significantly decreases GSH and GST activity in both rat kidney and liver. Dietary MAK-4 supplementation reversed this effect of cisplatin on liver and kidney GSH and GST activity (p<0.05). Thus, MAK-4 may protect against cisplatin-induced toxicity in patients receiving this type of chemotherapy.
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