Hypoglycemic, Hypolipidemic and General Beneficial Effects of an Herbal Mixture MA-471
Alternative Therapies in Clinical Practice, Vol. 3, No. 5, pp. 26-31, September/October 1996.
Amulya R. Sircar, MD,* Ramesh C. Ahuja, MD,* Shankar M. Natu, PhD,* Birendra Roy, MBBS,* and Hari M. Sharma, MD, FRCPC.**
**K.G. Medical College, Lucknow, India
**The Ohio State University, College of Medicine, Columbus, OH
An herbal mixture used for thousands of years in India for treatment of diabetes was evaluated for its efficacy and safety in patients with non-insulin-dependent diabetes mellitus (NIDDM). This herbal mixture, MA-471 (Glucomap™), was developed by Maharishi Ayurveda Products (Noida, India) and showed very good results in preliminary trials.
In the present pilot study, a clinical trial was conducted in which patients were divided into three groups: Group A (15 cases) were patients who had never taken an anti-diabetic drug and were uncontrolled by diet and exercise; Group B (30 cases) were patients controlled by an oral hypoglycemic agent (OHA); and Group C (15 cases) were patients uncontrolled by the maximum dose of an OHA.
All patients were started on MA-471 tablets after initial evaluation and blood collection, and were called for follow-up every two weeks for blood collection and observation of the improvement or deterioration of various symptoms.
The mean fasting and postprandial blood glucose, and hemoglobin A1C showed a significant decrease from the initial values in all three groups of patients. "Good" and "acceptable" control was achieved in 68.3% of the patients.
MA-471 seemed to be more effective in patients who had diabetes of less than five years duration. MA-471 also resulted in a significant fall in serum total cholesterol and triglycerides, and resulted in marked improvement in polyuria, fatigue, and constipation. This pilot study shows the herbal mixture MA-471 has significant hypoglycemic and hypolipidemic properties, and also improves the quality of life of NIDDM patients.
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