In Vitro Inhibition of Microsomal Lipid Peroxidation by MA-631, Student and Ladies Rasayana (SR and LR) and Maharishi Coffee Substitute (MCS)
The Pharmacologist, Vol. 34, No. 3, p. 184, 1992 (Abstract).
H.M. Sharma, A. Hanna, E.M. Kauffman, and H.A.I. Newman.
College of Medicine, The Ohio State University, Columbus, OH 43210
In this study, the effects of MA-631, SR, LR, and MCS on microsomal lipid peroxidation were examined in vitro. Rat liver microsomes were incubated with a sodium ascorbate and ADP-iron complex or with an NADPH-generating system to stimulate nonenzymatic or enzymatic lipid peroxidation, respectively. Aqueous or alcoholic extracts of MA-631, SR, LR, and MCS, when added to these incubation systems, inhibited hepatic microsomal lipid peroxidation in a dose-dependent manner. The alcoholic extracts were the most effective antiperoxidants in both systems. The alcoholic extract of MCS inhibited ascorbate- or NADPH-induced lipid peroxidation by 56% and 63%, with 12 micrograms and 22.5 micrograms, respectively. These findings suggest that these Maharishi Ayurvedaa food supplements may be useful in the treatment of free radical-induced injury due to their antiperoxidant properties.
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